|
KMID : 0390119940340010219
|
|
Journal of Pusan Medical College
1994 Volume.34 No. 1 p.219 ~ p.230
|
|
|
A Study on Clinical and Histopathological Findings, and Involucrin Expression of Epidermolytic Hyperkeratosis
|
|
박성민. 신항계. 권경술. 정태안
|
|
|
Abstract
|
|
|
Epidermolytic hyperkeratosis(EH) is a histopathologic term reported in various congenital and acquired skin diseases. But the pathogenesis of EH is not elucidated yet.
Throught the retrospective study, we reevaluated the clinical and histopathological findings in 21 cases representing epidermolytic hyperkeratosis(EH) histopathologically and studied the expression pattern of involucrin in order to understand the
pathogenesis of EH.
This clinical and histopathologic a investigation was made on the 5,200 biopsy specimens obtained from 1989 to 1991 at the Department of Dermatology in Pusan National University Hospital, and the immunohistochemical stain was done to examine the
expression of involucrin in EH.
@ES The results were as follows:
@EN 1. Congenital bullous ichthyosiform erythroderma(CBIE), palmoplantar keratoderma(PPK), and linear epidermal nevus(ELN) was found in 2, 27, and 62 cases, respectively, And all(100%) of 2 cases with CBIE, 5(185%) of 27 cases with PPK and
13(20.8%) of
62 cases with LEN showed the features of EH.
2. The onset of the diseases was at birth or under 1 year of age in most cases of CBIE, PPK and LEN. There were no family history in the cases with LEN.
3. Histopathologically, in 18 of 21 cases, pronounced EH finding was observed in upper spinous and granular layer, in 3 cases, also in lower spinous layer, and in 4 cases, in sweat gland duct. In 4 cases, binucleated cells were observed.
4. Expression of involucrin in EH was increased markedly compared with normal epidermis, and involucrin was also positive in parts of keratin layer.
There has been much debate upon the pathogenesis of EH whether EH is caused by accelerated differentiation of keratinocytes or by undifferentiation. We suppose that EH is caused by accelerated differentiation of keratinocytes by the fining of the
increased expression of involucrin, a marker of differentiation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|